PGS/PGD Testing in Orange County - Coastal Fertility, Irvine
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Preimplantation Genetic Diagnosis (PGS/PGD)

Offering one of the most affordable fertility treatment options.

On July 25, 1978, the first baby, Louise Brown, was born from a Reproductive Technology/IVF. The field of Reproductive Medicine is continually changing, as evidenced by the utilization of Intracytoplasmic Sperm Injection (ICSI), culturing embryos to Blastocyst, and utilizing genetic screening/evaluation of embryos prior to implantation PGD/PGS testing.

PGS/PGD testing consists of two categories:

  1. Preimplantation Genetic Screening or PGS testing for short – evaluation of chromosome abnormalities like Down’s Syndrome
  2. Preimplantation Genetic Diagnosis or PGD testing – looking for specific gene abnormalities like Cystic Fibrosis.

Studies show that there four high-risk groups of patients who have a greater likelihood for chromosome abnormalities (Aneuploidy):

  1. Women with advanced maternal age (AMA) > 38 years old
  2. Women with recurrent pregnancy loss (RPL)
  3. Women who fail 2 or more IVF cycles (FC) and
  4. Men with severe male factor (MF) < 1 million motile sperm.

In each of these groups, 70%-100% of the embryos may be abnormal. Thus proceeding with PGS test helps to determine which embryo to transfer.

PGS testing is done either at the day 3 (cleavage) stage where a single cell is removed and tested or the day 5 (blastocyst) stage where several cells are removed and tested. Embryo transfer is done only with those embryos that have normal chromosomes.

Coastal Fertility Medical Center has pioneered the use of PGD/PGS tests in Southern California and continues to be a leader in the field. It is our hope that we can provide valuable information to patients in an effort to allow them to make appropriate choices.