Causes of Infertility - Coastal Fertility Medical Center
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Causes of Infertility in Women

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There are a number of different causes of infertility that can impact a patient’s ability to get pregnant. Infertility can be caused by the male, the female or involve both partners. Below we have explained some of the more common causes of infertility in women. A separate page is dedicated to issues involving [intlink id=”149″ type=”page”]male factor infertility[/intlink].

Premature Ovarian Failure (POF)

Sometimes referred to as “premature menopause”, is a loss of ovarian function in women under 40 years of age. Periods stop, estrogen is low, and the [intlink id=”210″ type=”page”]follicle-stimulating hormone (FSH)[/intlink] level is elevated. Some women may experience premature ovarian failure because of adrenal, [intlink id=”212″ type=”page” anchor=”PituitaryG”]pituitary[/intlink], or [intlink id=”212″ type=”page” anchor=”Thyroid”]thyroid[/intlink] deficiencies. Radiation therapy and anti-cancer agents may achieve a cancer cure at the cost of Fertility by causing premature ovarian failure. Women with [intlink id=”212″ type=”page” anchor=”Turners”]Turner’s Syndrome[/intlink], a rare genetic disorder, do not develop functional [intlink id=”212″ type=”page” anchor=”Ovaries”]ovaries[/intlink] at all.

Endometriosis

Endometriosis, is believed to be quite common. It is estimated that between 25% and 50% of women with Infertility have endometriosis. This disorder develops when fragments of the endometrial lining are implanted in other areas of the pelvis. These endometrial, or misplaced tissue implants will still respond to a woman’s monthly hormonal cycle, causing pain and discomfort, slowly increasing in number and size with each menstrual cycle and eventually causing scarring and inflammation. Endometrial implants in the [intlink id=”212″ type=”page” anchor=”Ovaries”]ovaries[/intlink] or [intlink id=”212″ type=”page” anchor=”Fallopian”]fallopian tubes[/intlink] are particularly likely to cause [intlink id=”212″ type=”page” anchor=”Infertility”]infertility[/intlink], even if the endometriosis is mild.

Endometriosis-related causes of [intlink id=”212″ type=”page” anchor=”Conception”]conception[/intlink] difficulty may include organ damage, low levels of a molecule specific to enhancing [intlink id=”212″ type=”page” anchor=”Implantation”]implantation[/intlink], increased presence of peritoneal white blood cells, and dysfunctional immune system. Unfortunately, there exists no simple blood or urine test to detect this common affliction of the reproductive organs; the only true diagnosis is via [intlink id=”212″ type=”page” anchor=”Laparoscopy”]Laparoscopy[/intlink], a fortunately simple, yet still surgical, procedure.

» Watch Video: Endometriosis & Fertility

Polycystic Ovarian Syndrome (PCO, PCOS, PCOD)

Polycystic Ovarian Syndrome (also called Stein-Leventhal Syndrome) is a hormonal disorder that affects approximately six to ten percent of pre-menstrual women and is the major cause of [intlink id=”212″ type=”page” anchor=”Infertility”]infertility[/intlink] in American women. Polycystic Ovarian Syndrome is the result of the overproduction of hormones in a woman’s body. During [intlink id=”212″ type=”page” anchor=”Ovulation”]ovulation[/intlink], the [intlink id=”212″ type=”page” anchor=”Ovaries”]ovaries[/intlink] receive hormones from the [intlink id=”212″ type=”page” anchor=”PituiteryG”]pituitary gland[/intlink]. These hormones, [intlink id=”212″ type=”page” anchor=”FollicleS”]follicle-stimulating hormone (FSH)[/intlink] and [intlink id=”212″ type=”page” anchor=”Luteinizing”]luteinizing hormone (LH)[/intlink], help the egg reach maturity in preparation to be fertilized. In women with PCOS, there is an abnormal level of [intlink id=”212″ type=”page” anchor=”FollicleS”]FSH[/intlink] and [intlink id=”212″ type=”page” anchor=”Luteinizing”]LH[/intlink] being secreted. The overproduction of LH causes the ovaries to overproduce [intlink id=”212″ type=”page” anchor=”Androgens”]androgens[/intlink]. Increased androgen production produces high LH levels and low FSH levels, so the [intlink id=”212″ type=”page” anchor=”Follicle”]follicles[/intlink] are prevented from producing a mature egg. Thus the ovulatory process is not allowed to complete itself. The partially-developed egg (inside its follicle shell) dies. Without egg production, the follicles swell with fluid and form into cysts, and it is these cysts that create polycystic ovaries. Every time an egg is trapped within the follicle, another cyst forms, so the ovary swells, sometimes reaching the size of a grapefruit. Without [intlink id=”212″ type=”page” anchor=”Ovulation”]ovulation[/intlink], [intlink id=”212″ type=”page” anchor=”Progesterone”]progesterone[/intlink] is no longer produced, whereas estrogen levels remain normal.

Although Polycystic Ovarian Syndrome presents itself during adolescence or the early adult years, women often do not know they have the disorder until after they attempt to conceive. No two women affected by PCOS have the same symptoms. Common characteristics associated with PCOS are:

  • Insulin Resistance
  • Hyperandrogenison (Increased male hormones)
  • Polycystic ovaries
  • Irregular menstrual cycles (oligomenorrhea) or no menstrual cycles ([intlink id=”212″ type=”page” anchor=”Amenorrhea”]amenorrhea[/intlink])
  • Excessive facial and body hair growth (hirsutism)
  • Male pattern hair loss (androgenic alopecia)
  • Acne
  • Obesity/weight gain
  • Infertility

Pelvic Inflammatory Disease and Sexually Transmitted Diseases

Pelvic Inflammatory Disease (PID) is the major cause of [intlink id=”212″ type=”page” anchor=”Infertility”]infertility[/intlink] worldwide. PID includes a variety of infections caused by different bacteria that can affect the [intlink id=”212″ type=”page” anchor=”Uterus”]uterus[/intlink], [intlink id=”212″ type=”page” anchor=”Fallopian”]fallopian tubes[/intlink], [intlink id=”212″ type=”page” anchor=”Ovaries”]ovaries[/intlink], appendix, parts of the intestine that lie in the pelvic area, or, in the worst case, the entire pelvic area (peritonitis). The sites of infection most often implicated in Infertility are in the fallopian tubes, a condition known as [intlink id=”212″ type=”page” anchor=”Salpingitis”]Salpingitis[/intlink]. Although PID can be a result of non sterile abortions, use of an IUD, or a ruptured appendix, most infections are caused by sexually transmitted diseases. [intlink id=”212″ type=”page” anchor=”Chlamydia”]Chlamydia[/intlink] Trachomatis is an infectious organism that causes 75% of Salpingitis cases. A small US study suggests that Chlamydial infection of the upper genital tract, even without severe inflammation, may cause a higher proportion of fallopian ectopic pregnancies than previously thought. [intlink id=”212″ type=”page” anchor=”Gonorrhea”]Gonorrhea[/intlink] is responsible for most of the remaining cases. Severe or frequent attacks of PID can eventually cause scarring, abscess formation, and tubal damage that result in Infertility. The severity of the infection, not the number of the infections, appears to pose the greater risk for Infertility. About 20% of women who develop symptomatic PID become infertile. PID also significantly increases the risk of [intlink id=”212″ type=”page” anchor=”Ectopic”]ectopic pregnancy[/intlink].

Ovulation and Hormonal Disorders

Given the intricate interaction of the hormones necessary for [intlink id=”212″ type=”page” anchor=”Ovulation”]ovulation[/intlink], it is not surprising that about 33% of Infertility cases can be traced back to ovulation and hormonal problems. They may result in the failure of the ovarian follicle to rupture, an empty follicle, or entrapment of the egg so that it isn’t released. Various medical conditions, as well as lifestyle factors such as excessive exercise, eating disorders, smoking, or stress can change normal hormonal rhythm. Even slight irregularities in the hormonal system can result in ovulation disorder.

Fibroid Tumors

Benign fibroid tumors in the uterus are extremely common in women over 30. In rare cases, they can cause Infertility by interfering with the uterine cavity, blocking the fallopian tubes, or altering the position of the [intlink id=”212″ type=”page” anchor=”Cervix”]cervix[/intlink] and preventing [intlink id=”212″ type=”page” anchor=”Sperm”]sperm[/intlink] from reaching the [intlink id=”212″ type=”page” anchor=”Uterus”]uterus[/intlink]. High levels of estrogen seem to stimulate the growth of fibroid tumors; heredity may also play a role in their development.

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